"Idroarilazione catalizzata da oro di derivati enini N-eterociclici: ottimizzazione e scopo per la sintesi di N-eterocicli poliaromatici"

My MD research project deals with a hydroarylation reaction catalysed by gold(I) complexes, with the aim of synthesizing benzo-fused N-heterocycles. These products are of great interest and are currently employed in medical and pharmaceutical field. The substrates for the gold-catalysed reaction are lactam-derived enynes, which were achieved by a synthetic path starting from highly available and cheap reactants. Hereafter, different Au(I) catalysts were tested for the hydroarylation, both commercial and home-made in the laboratory. After this, the optimised procedure was employed to extend the scope. This way, we can obtain different functionalized heterocycles which may have practical applications.