MOLECULAR RECOGNITION STUDIES OF BIORELEVANT ANIONS WITH SQUARAMIDES-BASED RECEPTORS

Squaramide molecules have been studied for the last forty years. Their particular features, like aromatic structure, hydrogen donour and/or hydrogen acceptors, let us use them in a lot of chemical situations, like organocatalisis, supramolecular chemistry, protein inhibitors. In my work, I studied four kinds of squaramide receptors that could be used in the future for anion recognitions and transport. In particular, in my experimental work I used UV and NMR titration to find the association constants K1 and K2 between different anions and my four receptors in different environments (CHCl3/DMSO 99:1, CHCl3/DMSO 70:30 solvents for UV, CDCl3/DMSO 95:5 solvent for NMR). The anion chosen are chloride, pyrophosphate and phosphonoacetate. in all chloroform experiments, all the receptors give great interactions with pyrophosphate, and good ones with the other anions.