The direct insertion of a nucleophilic CH2-X unit into an hydrocarbon chain enables the formal introduction of the moiety with the precisely defined degree of functionalization. Herein, we report the controlled insertion of a methylene unit between the C-(sp2) carboxylic moiety and the α-carbon of an ester. By properly selecting the nucleophile added at the latest stage of the protocol, a divergent synthesis of amides or thioesters will be obtained.
Omologazione unicarboniosa mediata da carbenoidi di litio di esteri in ammidi e tioesteri: un accesso diretto agli analoghi carbossilici
RUGGIERO, LUCA
2021/2022
Abstract
The direct insertion of a nucleophilic CH2-X unit into an hydrocarbon chain enables the formal introduction of the moiety with the precisely defined degree of functionalization. Herein, we report the controlled insertion of a methylene unit between the C-(sp2) carboxylic moiety and the α-carbon of an ester. By properly selecting the nucleophile added at the latest stage of the protocol, a divergent synthesis of amides or thioesters will be obtained.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
893344_893344.lucaruggiero.tesi.pdf
non disponibili
Tipologia:
Altro materiale allegato
Dimensione
2.54 MB
Formato
Adobe PDF
|
2.54 MB | Adobe PDF |
I documenti in UNITESI sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Utilizza questo identificativo per citare o creare un link a questo documento:
https://hdl.handle.net/20.500.14240/86189