Evoluzione della sequenza/struttura del dominio N-terminale di FOXP2

FOXP2 was the first gene to be associated to a human language disorder and is considered a central regulatory hub in the molecular network underlying vocalization and language in humans and other animals. However, several aspects of the structure, function, and evolution of this transcription factor are still scarcely understood. To gain a better understanding of these issues, we have undertaken here an analysis of the N-terminal domain of FOXP2 through a combination of bioinformatics, biophysical, and cell biological approaches in search of possible biological roles.