Polyadenylation is an essential mechanism in which a poly(A) tail is added at the 3’ end of a messenger RNA. Many protein-coding genes have more than one polyadenylation site, and the functional impact of alternative polyadenylation (APA) is still debated in the scientific community. Here I put together various sources to present various points of view on the matter, describe the role of APA in the human body, the latest technological advancements in the study of this phenomenon, and speculate on future researches in this field.
Polyadenylation is an essential mechanism in which a poly(A) tail is added at the 3’ end of a messenger RNA. Many protein-coding genes have more than one polyadenylation site, and the functional impact of alternative polyadenylation (APA) is still debated in the scientific community. Here I put together various sources to present various points of view on the matter, describe the role of APA in the human body, the latest technological advancements in the study of this phenomenon, and speculate on future researches in this field.
Controversies Surrounding the Functional Impact of Alternative Polyadenylation
GIOANNINI, GIULIO
2019/2020
Abstract
Polyadenylation is an essential mechanism in which a poly(A) tail is added at the 3’ end of a messenger RNA. Many protein-coding genes have more than one polyadenylation site, and the functional impact of alternative polyadenylation (APA) is still debated in the scientific community. Here I put together various sources to present various points of view on the matter, describe the role of APA in the human body, the latest technological advancements in the study of this phenomenon, and speculate on future researches in this field.| File | Dimensione | Formato | |
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Tesi_Gioannini.pdf
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https://hdl.handle.net/20.500.14240/2650