Simulazione e analisi dati delle distribuzioni di Prompt Gamma Timing in proton-terapia nell'ambito del progetto MERLINO ​

The development of Adrotherapeutic treatments has led to the need to develop new tools for in vivo range monitoring. The technique explored in this thesis involves using Prompt Gammas (PG) emitted by fast nuclear de-excitations to make time-of-flight measurements. The data used during the analysis were collected during two beam tests, one carried out in December 2022 and one in July 2023, or obtained through simulations with FLUKA. After showing that the PG detection statistics follow a Poissonian model, the foundations were laid to develop robust analyses to compare PG timing distributions (PGT). Subsequently, both simulations and experimental data were used to assess the sensitivity of the system to range shifts.